Cerevast Therapeutics has recently completed the healthy volunteer phase of the Combined Lysis of Thrombus in Brain Ischemia with Transcranial Ultrasound in Brain Ischemia (CLOTBUST-HF), an NIH funded Phase I/II trial. In this initial phase of the study, 15 healthy volunteers were safely treated with two hours of continuous ultrasound insonation using the Cerevast ClotBust™-ER device.
The second phase of this study was initiated in September, 2009 in which acute ischemic stroke patients are being treated with the ClotBust™-ER device while receiving concomitant tPA therapy.
The study is being conducted at the University of Texas at Houston and the University of Alabama at Birmingham. Dr. James Grotta, M.D., Chairman of the Department of Neurology at the University of Texas Medical School at Houston and Director of the Stroke Program at Memorial Hermann – Texas Medical center serves as the Principal Investigator of the study.